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Portsmouth Hospitals University Trust are looking for volunteers to take part in a study looking at the use of different COVID-19 vaccines and doses for giving a third dose.

This study is being run by Portsmouth Hospitals University Trust, and is sponsored by University Hospital Southampton NHS Foundation Trust.

Who is eligible

You may be eligible to take part in the study if you:

  • Are aged 18-30 years old
  • Received 2 doses of BNT162b2 (Pfizer) or mRNA-1273 (Moderna) and are at least 3 months (84 days) since your second dose
  • Have not yet received a booster

You must be willing to tell the trial staff about your medical history, and you may be asked to allow the trial staff to check this with your General Practitioner (GP). Bear in mind that we would also notify your GP if you joined the trial (even if we did not need to check your medical history with them in advance).

You must agree not to donate blood during the trial.

What does the study involve?

Enrollment on the study would involve:

  • Screening and vaccination visit - 1.5 hours – review of medical history, vital signs, blood test, receive vaccine, up to 30 minute observation in clinic after the vaccine
  • Follow-up after vaccination- Electronic Symptom Diary “e-diary” – Completed at home
  • Follow-up visits – 30 minutes – vital signs, blood tests and check for side effects or new health problems

Your appointments will be at Portsmouth Research Hub, John Pounds Centre, 23 Queen Street, Portsmouth, PO1 3HN. There will be around 5 visits in total.


Portsmouth Hospitals University Trust will provide reimbursement up to £225 for your time, inconvenience and travel (depending on the total number of visits you attend). The total study participation time is up to 8 months.

Once enrolled you will be compensated for your time, the inconvenience of having blood tests and procedures, and your travel expenses. The total amount compensated will be approximately £225 depending on the total number of visits attended. Additional visits will be paid at a rate of £45/visit. Please ask the study team if you would like more information on how and when you will be reimbursed. Those who attend for final screening and vaccination visit (Day 0) but are not eligible to proceed further in the trial, will be reimbursed for their time.

Trial reimbursement will be made by bank transfer throughout the trial, so please bring your bank details with you to your screening visit (no cash payments can be made). If you would like more information on how and when you will be reimbursed, please ask your local study team. Should you decide to withdraw from the trial before it is completed, payment will be pro rata (you will receive a proportion of the total amount).

Sign up for the study

To sign up for the study, please contact the Portsmouth Research Hub Team at researchhub@porthosp.nhs.uk or 02392 892053 by Wednesday 30 March 2022.

The study team will then contact you to check your eligibility for the study based on the criteria listed in the section above. They will then be able to book you in for a screening visit that you can attend to fully enrol onto the study. Details of what will happen at this screening visit are listed in the section below titled “Enrolment on the Study”.

Ethics code: 21/SC/0171 (NHS)